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Research Outline
Prepared for Ify A. | Delivered October 12, 2020
Lung Cancer Correlations
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Goals
To provide proof of a correlation between lung cancer and people with mild to moderate lung health issues/concerns.
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Early Findings
Chronic Obstructive Pulmonary Disease (COPD)
A publication by the Journal of Thoracic Dieseases (
JTC
),
NCBI
, and
Cancer Network
, COPD is linked to a heightened risk of lung cancer in people who have never smoked.
COPD is a preventable and treatable condition characterised by
persistent respiratory symptoms
and enhanced inflammatory response due to noxious particles and gases.
JTC provided
epidemiological evidence
linking COPD and lung cancer.
People with COPD are said to be at
greater risk of lung cancer
, which suggests that shared pathological mechanisms such as chronic inflammation, epigenetic changes, and impaired DNA repair processes as a result of oxidative stress.
It also provided
genetic and epigenetic mechanisms
linking COPD and lung cancer.
Idiopathic pulmonary fibrosis (IPF)
An
NCBI publication
opined that IPF increases the risk of developing lung cancer by
7% to 20%
.
The prevalence of LC in IPF patients ranges from
2.7% to 48%
.
According to a publication by the
European Respiratory Journal
, "Idiopathic pulmonary fibrosis (IPF) was reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy."
The cancer is said to develop in the
area of major fibrosis
.
The study included "
63%
with combined lung cancer and IPF (IPF-CA), 218 patients with lone IPF, and 2,660 patients with primary lung cancer. All patients were diagnosed at Asan Medical Center during the same period."
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