People with COPD are said to be at greater risk of lung cancer, which suggests that shared pathological mechanisms such as chronic inflammation, epigenetic changes, and impaired DNA repair processes as a result of oxidative stress.
The prevalence of LC in IPF patients ranges from 2.7% to 48%.
According to a publication by the European Respiratory Journal, "Idiopathic pulmonary fibrosis (IPF) was reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy."
The study included "63% with combined lung cancer and IPF (IPF-CA), 218 patients with lone IPF, and 2,660 patients with primary lung cancer. All patients were diagnosed at Asan Medical Center during the same period."
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