To provide anoverview of the use of linzess in IBS, its benefits, INDICATIONS, SIDE EFFECTS, contraindications, and patient reviews.
Linzess is a 14-amino acid peptide that functions as a guanylate cyclase-C (GC-C) agonist that "acts on the luminal surface of the intestinal epithelium."
Upon activation of GC-C, an "increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP)" is observed, which leads to the secretion of chloride and bicarbonate into the intestinal lumen. This results in "increased intestinal fluid and accelerated transit."
The recommended dose of Linzess is 290 mcg every day daily for IBS patients.
The drug should be taken on an empty stomach, 30-60 minutes prior to the first meal of the day.