Prepared for Onikepe A. | Delivered June 1, 2020
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To provide anoverview of the use of linzess in IBS, its benefits, INDICATIONS, SIDE EFFECTS, contraindications, and patient reviews.
Linzess is a 14-amino acid peptide that functions as a guanylate cyclase-C (GC-C) agonist that "
acts on the luminal
surface of the intestinal epithelium."
Upon activation of GC-C, an "
increase in both intracellular
and extracellular concentrations of cyclic guanosine monophosphate (cGMP)" is observed, which leads to the secretion of chloride and bicarbonate into the intestinal lumen. This results in "increased intestinal fluid and accelerated transit."
The recommended dose of Linzess is
290 mcg every
day daily for IBS patients.
The drug should be taken on an empty stomach,
30-60 minutes prior
to the first meal of the day.
capsules need to be s
According to studies performed by the FDA, linzess decreases the
pain in IBS patients
The drug also helps patients with their stool frequency, by allowing them to empty their colon
47.6% more frequently
The biggest side effects associated with the drug is the
that is usually followed after taking the pill.
In some rare cases, the patient might also experience abdominal pain and flatulence.
Linzess is indicated for adults for the treatment of
irritable bowel syndrome
with constipation (IBS-C) and chronic idiopathic constipation (CIC).
Linzess is contraindicated in patients that are
younger than 6
because of the risk of dehydration.
It is also contraindicaterd in patients that have
mechanical gastrointestinal obstruction
The majority of patients are actually very happy with the dug, noting that it helps them
However, the majority of them have noted that the
diarrhea is a big problem
, which is what prevents them from taking the drug more often.