Heart Failure Therapy: Innovation


To identify examples of innovation in the heart failure and heart failure therapy spaces (drugs, devices, treatments, etc) to understand the market. The information required include: what the innovation is, the current state of it, pros/cons/customer review examples, how it is being disruptive, and what is next for the company or product.

Early Findings

Innovations in heart failure treatment

  • According to JACC, until recently there has been relatively little innovation within the chronic heart failure space and had involved standard medications such as beta-blockers, angiotensin-converting enzyme inhibitors, and diuretic agents to treat symptoms. Based on clinical trials, new drugs that have recently been approved are able to reduce death and hospitalization due to heart failure by 20%.
  • Web MD mentions several advances in heart failure treatment. These include: new drugs as such Ivabradine (Corlanor) and Sacubitril/Valsartan (Entresto). These drugs are also mentioned in this journal article. Among other innovations are implants and heart pumps such as the implantable cardioverter defibrillator, cardiac resynchronization therapy, left ventricular assist device (LVAD), implantable monitor, and new surgeries and tests such as reconstruction surgery and genetic testing.
  • According to CBNC, many heart patients rely on medications, pacemakers (cardiac resynchronization therapy-CRT), implantable cardiac defibrillators (ICD), and ventricular assistance devices. As a result of the breakthroughs in sensors and nanotechnology during the past year, patients now have access to safer and more reliable CRT and ICD devices.
  • CBNC further reports that during the past 5 years research has been focused on developing new technologies to monitor patients before the symptoms actually start. One such innovation is the SensiVest developed by Sensible Medical to monitor fluid buildup in the lungs. According to a study, this device had been able to reduce hospital readmission by 87%.
  • Some of the most futuristic innovations in heart failure devices come from the field of soft robotics. Among such innovations include the customizable soft robotic sleeve developed by Harvard University and Boston Children’s Hospital that fits around the heart in sync with the natural heartbeat to help pump blood (also featured in an article by Healthcare Weekly).
  • Pumping Marvellous (heart failure charity) has mentioned several innovations in the heart failure space such as Sacubitril Valsartan (drug innovation), CardioMEMS, and Mitra Clip (medical technology innovation).
  • Healthcare Weekly highlights some of the latest technologies in treating heart failure. These include stem cell therapy (e.g CardiAMP™ Therapy and CardiALLO™ Therapy developed by BioCardia), implantable defibrillators, Robotic sleeve, 3D bioprinted heart tissue, and AI algorithms.

Proposed next steps:

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